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To test whether chemicals are toxic to humans, researchers need to use liver cells that have been freshly harvested from mice or other mammals. A new collection of stable cell lines, described in BMC ...

Change often involves a pivotal event that builds on previous history and opens the door to a new era. Pivotal events in science include the discovery of penicillin, the elucidation of the DNA double ...

The European Commission has revealed details of a major new research programme to develop a modern, high-throughput approach to repeat-dose toxicity testing. Pressure to launch such an effort arose ...

Challenging risk assessment methods used for decades by toxicologists, a new review of the literature suggests that oral gavage, the most widely accepted method of dosing lab animals to test chemical ...

Biocompatibility testing is a necessary part of any medical device validation process. It is governed by FDA’s ISO 10993 guidance document, a seemingly rigid statement that provides a general matrix ...

Experimenting on animals is a dark side of science and research. And most of us try not to think about the animals that ...

Representatives from four international agencies, including the director of the U.S. National Toxicology Program (NTP), today signed a memorandum of cooperation that could reduce the number of animals ...

Federal regulators in the United States are pushing harder than ever to reduce and eventually replace animal testing in drug ...

To test whether chemicals are toxic to humans, researchers need to use liver cells that have been freshly harvested from mice or other mammals. A new collection of stable cell lines, described in BMC ...